Formulation Development of Bilayer Tablets of Carvedilol Phosphate

The aim of the current investigation is to design oral once daily bi layer tablets of carvedilol phosphate, which release the drug for 24 hours and match with marketed extended release capsule. The basic objective was to develop a generic version of anti hypertensive tablets in line with the innovator. A generic version of Tablets was developed that is safe, efficacious and bio equivalent to the reference product.The tablets were prepared by the direct compression method using hydrophilic and hydrophobic polymers in different combinations. Anti hypertensive tablets formulated by direct compression showed comparable result with innovator. The techniques employed were practically simple and commercial exploited.

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